Krystal Biotech, Inc. (KRYS)

Healthcare · NMS · US

USD341.79+5.70% today

Fundamentals

Market capUSD10.01B
P/E ratio48.6
Revenue growth (YoY)+31.9%
Profit margin53.9%
Return on equity19.9%
52-week rangeUSD130.50 to USD382.54
Next earnings2026-08-03

Valuation and ratings

DCF fair valueUSD269.11
Upside to fair value-21.3%
Analyst target (mean)USD361.67
Analyst rangeUSD241.00 to USD474.00
Analysts covering9
Consensus viewstrong buy
Moat score86/100
Overall rating55/100, Buy

Krystal Biotech, Inc. trades at USD341.79, which is 21% above the USD269.11 our discounted cash flow model puts on the business. On that measure it screens as expensive, which is not the same as saying it will fall.

Our moat model scores it 86 out of 100, which is a wide moat. A moat is a structural reason competitors cannot take the profits away, and it matters more to a long holding period than any single quarter's numbers do.

It changes hands at 48.6 times earnings. Be careful reading that in isolation: for a cyclical business a low P/E arrives at the top of the cycle, when profits are peaking and about to fall, which is exactly when the shares look cheapest and are not.

About Krystal Biotech, Inc.

Krystal Biotech, Inc., a commercial-stage biotechnology company, discovers, develops, manufactures, and commercializes genetic medicines to treat diseases with high unmet medical needs in the United States. The company commercializes VYJUVEK (beremagene geperpavec-svdt, or B-VEC) for the treatment of dystrophic epidermolysis bullosa (DEB). It also develops KB803 for ocular complications of dystrophic epidermolysis bullosa; KB801 for neurotrophic keratitis; KB407, which is in Phase 1 clinical trials for treating cystic fibrosis; KB111 for Hailey-Hailey disease; KB707 for solid tumors; KB304 for dynamic wrinkles; KB707 that is in Phase 1/2 clinical trials for the treatment of anti-PD-1 relapsed/refractory; KB408, which is in Phase 1 clinical trials for treating Alpha-1 antitrypsin deficiency; and KB301 that is in Phase 2 clinical trials for treating aesthetic skin conditions, as well as in open label study with ophthalmic B-VEC for treating for ocular complications of deb. Krystal Biotech, Inc. was founded in 2016 and is headquartered in Pittsburgh, Pennsylvania.

Industry: BiotechnologyEmployees: 295HQ: United States

KRYS passes 5 of our 30 screens today

Each screen prints the exact criteria it used, and the circumstances in which it is wrong.

Common questions

Is Krystal Biotech, Inc. (KRYS) undervalued?

Against our discounted cash flow estimate of USD269.11, KRYS at USD341.79 is 21% above fair value. That is one model's answer, not a recommendation, and most of a DCF's output sits in a terminal value nobody can forecast.

What is KRYS's P/E ratio?

KRYS trades at 48.6 times earnings. A low P/E is not automatically cheap: on a cyclical company it is usually a warning that earnings are at a peak.

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Data from company filings, exchange quotes and SEC EDGAR 13F disclosures. Quotes are delayed. Metrics we do not have are left out rather than estimated. Educational information, not financial advice.